Docetaxel Micelles: A New Formulation to Diminish Hypersensitivity Reactions

Docetaxel Micelles: A New Formulation to Diminish Hypersensitivity Reactions

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Background/Objectives: Docetaxel is a potent anti-cancer agent capable of treating various types of cancer.However, it often induces a range of adverse reactions when used with its standard solubilizer, click here Tween-80, necessitating allergy prophylaxis with dexamethasone prior to administration.To mitigate the risk of allergic reactions, with nanomicelles garnering significant interest due to their enhanced solubility and thermodynamic stability.Methods: In this research, a mPEG-PLA-Lys(Fmoc) micellar copyright with m = 45 and n = 10 was engineered to encapsulate docetaxel, and its self-assembly into micelles was investigated.

Additionally, allergic reaction studies were conducted on animals.Results: The findings indicated that the formulation did not cause hemolysis, vascular, or muscle irritation in rabbits, nor did it elicit an allergic response in guinea pigs.Conclusions: These results suggest that nanomicelle-encapsulated docetaxel can diminish the allergic here reactions associated with docetaxel injections, offering a novel approach to enhance the therapeutic utility of this outstanding anti-cancer drug.